Xanthine Oxidase Inhibition For The Treatment Of Cardiovascular Disease: A Systematic Review and Meta-Analysis

摘要: Summary Background Xanthine oxidase inhibition (XOI) reduces oxidative stress in the vasculature. Moreover it uric acid levels, a risk factor for development of cardiovascular disease. As such, XOI holds potentially dual mechanism treatment disease. Aims Through systematic review, we sought to clarify extent available evidence that has evaluated effect upon clinical or surrogate markers disease and function humans. Methods A search strategy was used interrogate Ovid Medline (1950–June Week 4 2010) Embase (1980–2010 25) databases, identify relevant studies. Meta-analysis planned frequently studied endpoints. Results Thirty-eight publications (reporting 40 studies) were identified. There heterogeneity between studies all aspects study design, including outcome measures interest. Prospective assessment predominated. Combined meta-analysis feasible three parameters, with favorable modifications each following xanthine inhibition: brachial artery flow mediated dilatation (five studies: n = 75, control 69) increased by 2.50% (95% CI, 0.15–4.84); forearm blood responses acetylcholine infusion 74, 74) 68.80 18.70–118.90; percent change relative noninfused arm); circulating (malondialdehyde, six 78, 68) reduced 0.56 nmol/mL 0.26–0.87). Conclusions XOI improves endothelial patients with, at of, Large prospective examining definitive end points are lacking but now appear indicated.