Randomised controlled trial of escitalopram for cervical dystonia with dystonic jerks/tremor

摘要: Objective: Trials for additional or alternative treatments cervical dystonia (CD) are scarce since the introduction of botulinum neurotoxin (BoNT). We performed first trial to investigate whether dystonic jerks/tremor in patients with CD respond selective serotonin reuptake inhibitor (SSRI) escitalopram. Methods: In a randomised, double-blind, crossover trial, received escitalopram and placebo 6 weeks. Treatment BoNT was continued, scores on rating scales regarding dystonia, psychiatric symptoms quality life (QoL) were compared. Primary endpoint proportion that improved at least one point Clinical Global Impression Scale scored by independent physicians experience movement disorders. Results: Fifty-threepatients included. period, 14/49 (29%) severity versus 11/48 (23%) period (P=0.77). There no significant differences between baseline after treatment jerks/tremor. Psychiatric QoL significantly both periods compared baseline. scales. During escitalopram, experienced slightly more adverse events, but serious events occurred. Conclusion: this innovative add-on effect jerks found motor symptoms. However, we also did not find reason withhold SSRIs depression anxiety, which common dystonia.