Drug Resistance Patterns and Virus Re-Suppression among HIV-1 Subtype C Infected Patients Receiving Non-Nucleoside Reverse Transcriptase Inhibitors in South Africa

摘要: Background: Emergence of HIV-1 drug resistance is at times an inevitable and anticipated consequence antiretroviral therapy (ART) failure. We examined patterns virus re-suppression among subtype C-infected South African patients receiving first-line ART. Methods: Treatment records 431 on NNRTI-containing regimens for a median 45 months were analyzed. Patients with viral load (VL) >400 copies/mL followed mutations (DRM) re-assessed. Associations between clinical/demographic measures resistance/virologic outcomes using Fisher exact ordinal logistic regression. Results: Ten percent (43/431) viremic enrollment (98%) sequences obtained from 38/43. Of those, 82% had 1-7 DRM. In bivariate analysis remote exposure to single-dose nevirapine or prior ART; higher CD4 counts; lower VL; >6 virologic failure significantly associated number 25 8 continued regimen, 12 (48%) re-suppressed, six K103N three M184V. Thirteen (52%) which was detectable VL Conclusion: Among these patients, DRM numbers sub-optimal ART, adherence duration Viral in the presence M184V challenges assumptions about resistance. resource-limited settings, where genotyping alternative options are unavailable, continuing treatment, reinforcing regular monitoring may be effective even after