Epstein-Barr virus (EBV) gene expression in EBV-positive peripheral T-cell lymphomas.

摘要: Abstract Epstein-Barr virus (EBV) DNA has been detected in peripheral T-cell lymphomas. In this study, analysis of the EBV termini indicated that infection was clonal and nonpermissive. Analysis viral expression processed, spliced mRNAs representing EBNA1, LMP1, LMP2, BamHI A transcripts all EBV-positive The LMP1 protein by immunofluorescence a single specimen. contrast, neither EBNA2 nor mRNA were detected. These data indicate EBV-infected lymphomas are expansions cell with pattern gene which is distinct from Burkitt's or posttransplant but similar to nasopharyngeal carcinomas.