Tamoxifen: a review of its pharmacological properties and therapeutic use in the treatment of breast cancer.
作者： R.C. Heel , R.N. Brogden , T.M. Speight , G.S. Avery
DOI: 10.2165/00003495-197816010-00001
关键词:
摘要: Synopsis: Tamoxifen1 is a triphenylethylene oestrogen antagonist which has partial agonist activity in some species. Most therapeutic trials with tamoxifen have involved postmenopausal women advanced breast cancer, about 25 to 60% of patients showing improvement while receiving treatment (usually 20 or 40mg daily); however, poorly defined assessment criteria studies make it difficult compare the results different authors. 7 18% had complete clinical remissions lasting for few months several years.
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