作者: E.H. Quik , T.L. Feenstra , D. Postmus , B.J. Slotman , C.R. Leemans
DOI: 10.1016/J.EJCA.2016.04.008
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摘要: Abstract Background and purpose Proton therapy is an emerging technique in radiotherapy which results less dose to the normal tissues with similar target than photon therapy, current standard. Patient-level simulation models support better decision making on patients would benefit most. Materials methods A model was developed tracking individual patients' status regarding primary tumour multiple complications. As a proof of principle, populated based information from cohort 1013 head neck cancer patients. Dose–volume parameters for proton radiation treatment plans were then fed into compare outcomes terms length quality life select that Results The illustrative could adequately replicate cohort. Improvements varied considerably between projects medium-term specific individuals determines benefits applying rather therapy. Conclusions While needs be more especially recent data before being fully ready use clinical practice, it already distinguish high low potential Benefits are highest both good prognosis expected damage adjacent organs. allows selecting such priori patient relevant outcomes.