TNFAIP8 Regulates Intestinal Epithelial Cell Differentiation and May Alter Terminal Differentiation of Secretory Progenitors.
作者： Jason R. Goldsmith , Youhai H. Chen , Ryan Hood
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摘要: The intestine is a highly proliferative dynamic environment that relies on constant self-renewal of the intestinal epithelium to maintain homeostasis. Tumor necrosis factor-alpha-induced protein 8 (TNFAIP8 or TIPE0) regulator PI3K-mediated signaling. By binding PIP2 and PIP3, TIPE family members locally activate PI3K activity while globally inhibiting through sequestration membranous PIP2. Single-cell RNA sequencing survey Tipe0-/- small was used investigate role TIPE0 in differentiation. cells were shown shift towards an undifferentiated state, with notable exception goblet cells. Additionally, three possible novel regulators terminal cell fate decisions secretory lineage identified: Nupr1, Kdm4a, Gatad1. We propose these drive changes involved (Nupr1) tuft (Kdm4a Gatad1) commitment may play orchestrating
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