Age-related changes in the rate of esterification of plasma cholesterol in Fischer-344 rats.
作者： Shirley I. Carlile , B.J. Kudchodkar , C.S. Wang , Andras G. Lacko
DOI: 10.1016/0047-6374(86)90028-X
关键词:
摘要: Abstract Plasma cholesterol and triglyceride levels selected molecular species of plasma cholesteryl esters triglycerides were determined in 6-, 12-, 15-, 18-, 21- 24-month-old Fischer-344 rats. Lecithin:cholesterol acyltransferase (LCAT) activity was also using two independent methods utilizing endogenous exogenous substrates. increased up to 18 months age then plateaued. Of the investigated (C50, C52, C54 C56), only C52 linearly with age. The concentration other did not change fractional rate esterification showed a decreasing trend age, whereas, net gradual related increase. However, this latter parameter remained unchanged when data normalized for body weight. rates measured an substrate (estimating LCAT enzyme levels) essentially no These indicate that changes and/or composition lipoprotein substrate(s) are likely causes observed age-related esterification. significantly correlated animals all groups treated as one experimental group.
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