Tubular kidney injury molecule-1 (KIM-1) in human renal disease

摘要: KIM-1, a transmembrane tubular protein with unknown function, is undetectable in normal kidneys, but markedly induced experimental renal injury. The KIM-1 ectodomain cleaved, detectable urine, and reflects damage. expression human biopsies its correlation urinary (uKIM-1) unknown. In from various diseases (n = 102) controls 7), the fraction of positive tubules different damage parameters were scored. Double labelling was performed for macrophages (MO), a-smooth muscle actin (alpha-SMA), proximal (aquaporin-1) distal (E-cadherin) markers dedifferentiation marker (vimentin). uKIM-1 at time biopsy 53) measured by ELISA. Renal significantly increased all versus (p <0.05), except minimal change. KIM-I primarily expressed luminal side dedifferentiated tubules, areas fibrosis (a-SMA) inflammation (NIO). Independent disease, correlated positively damage, negatively not proteinuria. patients (P <0.001), including change, tissue MO, conclusion, upregulated disease associated inflammation. also indicating that it can be used as non-invasive biomarker disease. Copyright (c) 2007 Pathological Society Great Britain Ireland. Published John Wiley & Sons, Ltd.