Clinicopathological Features of Growth Hormone-Producing Pituitary Adenomas in 242 Acromegaly Patients: Classification according to Hormone Production and Cytokeratin Distribution
作者： Ryosuke Mori , Naoko Inoshita , Junko Takahashi-Fujigasaki , Tatsuhiro Joki , Hiroshi Nishioka
DOI: 10.1155/2013/723432
关键词:
摘要: The aim of this study was to clarify the relationship between histological features GH-producing adenomas surgically resected at Toranomon Hospital and clinical patients. Histological examinations, including immunohistochemistry for anterior pituitary hormones cytokeratin (CK), were performed on 242 consecutively excised adenomas. Immunohistochemistry showed 45% be monohormonal 55% plurihormonal, producing GH-PRL (77%), GH-TSH (13%), GH-PRL-TSH (10%). One-fourth GH had a dot-like pattern CK immunoreactivity in majority tumor cells (>80%); they significantly more common female or younger patients usually tended larger invasive than with perinuclear CK. Interestingly, CK-immunonegative found only 5% patients; also tendency larger, suggesting that are distinct type adenoma clinically aggressive features. Serum hormone levels correlated well size immunoreactivity. Each subtype adenoma, classified according immunoreactivity, associated characteristics. This information is useful understanding pathophysiology acromegaly-causing
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researchgate.net 参考文章(27)
Sylvia L. Asa, Tumors of the pituitary gland American Registry of Pathology , Armed Forces Institute of Pathology. ,(2011)
Mordechai Bodner, Michael Karin, A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells. Cell. ,vol. 50, pp. 267- 275 ,(1987) , 10.1016/0092-8674(87)90222-4
Ikuo Kobayashi, Hidehiro Oka, Heiji Naritaka, Yuichi Sato, Kiyotaka Fujii, Toru Kameya, Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas. Endocrine Pathology. ,vol. 13, pp. 83- 98 ,(2002) , 10.1385/EP:13:2:83
Eva Horvath, Kalman Kovacs, Pathology of acromegaly. Neuroendocrinology. ,vol. 83, pp. 161- 165 ,(2006) , 10.1159/000095524
HIROSHI BANDO, TOSHIAKI SANO, TSUTOMU OHSHIMA, CHEN-YU ZHANG, RYUICHI YAMASAKI, KEIZO MATSUMOTO, SHIRO SAITO, Differences in pathological findings and growth hormone responses in patients with growth hormone-producing pituitary adenoma. Endocrinologia Japonica. ,vol. 39, pp. 355- 363 ,(1992) , 10.1507/ENDOCRJ1954.39.355
K. Kovacs, Pathology of growth hormone excess. Pathology Research and Practice. ,vol. 183, pp. 565- 568 ,(1988) , 10.1016/S0344-0338(88)80011-6
M. Kasper, P. Stosiek, G. N. P. van Muijen, R. Moll, Cell type heterogeneity of intermediate filament expression in epithelia of the human pituitary gland. Histochemistry and Cell Biology. ,vol. 93, pp. 93- 103 ,(1989) , 10.1007/BF00266853
Akiko Yoneda, Toshiaki Sano, Shozo Yamada, Abdulkader Obari, Zhi Rong Qian, Elaine Lu Wang, Naoko Inosita, Eiji Kudo, Pituitary Adenomas that Show a Faint GH-Immunoreactivity but Lack Fibrous Body: Pit-1 Adenoma with Endocrinologically Low Activity Endocrine Pathology. ,vol. 21, pp. 40- 47 ,(2010) , 10.1007/S12022-009-9105-Z
Stuart Adler, Marian L. Waterman, Xi He, Michael G. Rosenfeld, Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain Cell. ,vol. 52, pp. 685- 695 ,(1988) , 10.1016/0092-8674(88)90406-0
Robert Y. Osamura, Noboru Egashira, Hanako Kajiya, Mao Takei, Maya Tobita, Takashi Miyakoshi, Chie Inomoto, Susumu Takekoshi, Akira Teramoto, Pathology, pathogenesis and therapy of growth hormone (GH)-producing pituitary adenomas: technical advances in histochemistry and their contribution. Acta Histochemica Et Cytochemica. ,vol. 42, pp. 95- 104 ,(2009) , 10.1267/AHC.09004