Drug Permeation through Membranes III: Effect of pH and Various Substances on Permeation of Phenylbutazone through Everted Rat Intestine and Polydimethylsiloxane

摘要: Abstract The permeation rate of phenylbutazone through membranes polydimethylsiloxane and everted rat intestine was measured over a range pH values. classical pH-partition hypothesis not obeyed. Permeability coefficients were calculated using modification Higuchi's general equation relating rate. effect various substances on the permeability coefficient determined. Phenylbutazone rates in one or both decrease presence gelatin, methylcellulose, polyvinylpyrrolidone, skim milk, albumin, sodium lauryl sulfate, polysorbate 80, cetrimonium bromide. Permeation enhanced by bile salt concentrations below the cmC porcine mucin, while unaffected. Substances having no apparent were: lactose, starch, talc, kaolin, calcium chloride, acacia, sucrose, saccharin, cholesterol, ferrous magnesium stearate.