Lipid regulation of cell membrane structure and function.
作者： Philip L. Yèagle
DOI: 10.1096/FASEBJ.3.7.2469614
关键词:
摘要: Recent studies of structure-function relationships in biological membranes have revealed fundamental concepts concerning the regulation cellular membrane function by lipids. Considerable progress has been made understanding roles played two lipids: cholesterol and phosphatidyl-ethanolamine. Cholesterol shown to regulate ion pumps, which some cases show an absolute dependence on for activity. These suggest that essential role plays mammalian cell biology is enable crucial enzymes provide necessary survival. Studies phosphatidylethanolamine protein activity morphology led hypotheses this particular lipid membranes. New information lipid-protein interactions nature head groups permitted development mechanistic In addition, intermediates lamellar-nonlamellar phase transitions systems containing phosphatidylethanolamine, or other lipids with similar properties, recently implicated facilitating fusion. Finally, transmembrane movement provided new insight into asymmetry biogenesis kinds are harbingers a generation field
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