Increased expression of ZBP-89 and its prognostic significance in hepatocellular carcinoma
作者： Chris ZY Zhang , Yun Cao , Jing‐Ping Yun , George G Chen , Paul BS Lai
DOI: 10.1111/J.1365-2559.2011.04136.X
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摘要: Zhang C Z Y, Cao Yun J P, Chen G & Lai P B S (2012) Histopathology 60, 1114–1124 Increased expression of ZBP-89 and its prognostic significance in hepatocellular carcinoma Aims: plays a role cell growth death. Its carcinoma (HCC) is not well documented. This study aimed to analyse HCC. Methods results: We examined five HCC lines 182 tissue samples by reverse transcription–polymerase chain reaction (RT–PCR), Western blot analysis immunofluorescence staining. Our results showed that the was higher than adjacent non-tumour liver, at both mRNA protein levels. localized nucleus most samples, but found cytoplasm 11.5% cases. Patient survival those tumours showing high better with low expression. High tended be more common World Health Organization (WHO) grade I grades II–IV HCC. There significant association between HBV positivity Colony formation reduced dramatically which overexpression demonstrated; this appeared correlate increased apoptosis, inferred finding elevated levels cleaved poly(ADP-ribose)polymerases (PARP), probable mechanisms for may involve p53 or p21 expression. Conclusions: has anti-tumour properties potential biomarker prognosis
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