In search of the Somogyi effect.
作者： E.A.M. Gale , A.B. Kurtz , R.B. Tattersall
DOI: 10.1016/S0140-6736(80)90233-0
关键词:
摘要: Abstract Insulin-treated diabetic patients may show a rapid swing to hyperglycaemia after episodes of hypoglycaemia. This rebound hyperglycaemia, or Somogyi effect, is thought be caused by the unopposed actions hormonal antagonists insulin secreted in response To test this theory study was made 15 who had 17 asymptomatic untreated hypoglycaemia (blood-glucose less than 2 mmol/l) between 11 P.M. and 3 A.M. After nocturnal hypoglycaemia, mean fasting blood-glucose concentrations at 7 ranged from 0·7-17 mmol/l were over 6 patients. These with apparent did not have higher levels growth hormone, cortisol, glucagon those little no recovery blood-glucose. There close inverse correlation (r= -0·996, p
sci-hub.se 参考文章(11)
Marvin E. Bloom, Daniel H. Mintz, James B. Field, Insulin-induced posthypoglycemic hyperglycemia as a cause of “brittle” diabetes The American Journal of Medicine. ,vol. 47, pp. 891- 903 ,(1969) , 10.1016/0002-9343(69)90203-4
JillD. Nelson, A.Michael Albisser, ErrolB. Marliss, Bernard Zinman, ROLE OF CONTINUOUS COMPONENT IN SUBCUTANEOUS "OPEN-LOOP" INSULIN DELIVERY The Lancet. ,vol. 315, pp. 1383- 1386 ,(1980) , 10.1016/S0140-6736(80)92654-9
M. I. Schmidt, A. Hadji-Georgopoulos, M. Rendell, S. MargoliS, D. Kowarski, A. A. Kowarski, Fasting Hyperglycemia and Associated Free Insulin and Cortisol Changes in “Somogyi-Like” Patients Diabetes Care. ,vol. 2, pp. 457- 464 ,(1979) , 10.2337/DIACARE.2.6.457
P M Brown, C V Tompkins, S Juul, P H Sonksen, Mechanism of action of insulin in diabetic patients: a dose-related effect on glucose production and utilisation. BMJ. ,vol. 1, pp. 1239- 1242 ,(1978) , 10.1136/BMJ.1.6122.1239
Erika Bruck, Margaret H MacGillivray, Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus. Pediatric Research. ,vol. 9, pp. 535- 541 ,(1975) , 10.1203/00006450-197506000-00005
Erika Bruck, Margaret H. MacGillivray, Posthypoglycemic hyperglycemia in diabetic children The Journal of Pediatrics. ,vol. 84, pp. 672- 680 ,(1974) , 10.1016/S0022-3476(74)80008-9
Michael Somogyi, Exacerbation of diabetes by excess insulin action The American Journal of Medicine. ,vol. 26, pp. 169- 191 ,(1959) , 10.1016/0002-9343(59)90307-9
Arlan L. Rosenbloom, Chronic Overtreatment With Insulin in Children and Adolescents Archives of Pediatrics & Adolescent Medicine. ,vol. 131, pp. 881- 885 ,(1977) , 10.1001/ARCHPEDI.1977.02120210059012
E.A.M. Gale, R.B. Tattersall, UNRECOGNISED NOCTURNAL HYPOGLYCÆMIA IN INSULIN-TREATED DIABETICS The Lancet. ,vol. 313, pp. 1049- 1052 ,(1979) , 10.1016/S0140-6736(79)92950-7
Daniel H. Mintz, Joseph L. Finster, Andrew L. Taylor, Alexander Fefer, Hormonal genesis of glucose intolerance following hypoglycemia The American Journal of Medicine. ,vol. 45, pp. 187- 197 ,(1968) , 10.1016/0002-9343(68)90037-5