Methods and compositions for the treatment of cancer
作者： Adi Gilboa-Geffen , Judy Lieberman , Lee Adam Wheeler
DOI:
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摘要: Described herein are methods and compositions relating to the treatment of cancer, e.g., breast using, aptamer-siRNA chimera molecules.
lens.org 参考文章(35)
David Spetzler, Tassilo Hornung, Valeriy Domenyuk, Frank Schafer, David Halbert, Nianqing Xiao, Aptamers and uses thereof ,(2013)
Wei Duan, Epcam aptamer for detection of cancer stem cells EpCAM Aptamer for Detection of Cancer Stem Cells. ,(2013)
Nithya Subramanian, Jagat R. Kanwar, Rupinder K. Kanwar, JagadeeshBabu Sreemanthula, Jyotirmay Biswas, Vikas Khetan, Subramanian Krishnakumar, EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer PLOS ONE. ,vol. 10, pp. e0132407- 19 ,(2015) , 10.1371/JOURNAL.PONE.0132407
Eli Gilboa, Fernando Pastor, Aptamer-targeted sirna to inhibit nonsense mediated decay ,(2010)
Jiehua Zhou, Katrin Tiemann, John Rossi, Britta Vallazza, RNA aptamers against BAFF-R as cell-type specific delivery agents and methods for their use ,(2015)
Adi Gilboa-Geffen, Peter Hamar, Minh T.N. Le, Lee Adam Wheeler, Radiana Trifonova, Fabio Petrocca, Anders Wittrup, Judy Lieberman, Gene knockdown by EpCAM aptamer-siRNA chimeras suppresses epithelial breast cancers and their tumor-initiating cells Molecular Cancer Therapeutics. ,vol. 14, pp. 2279- 2291 ,(2015) , 10.1158/1535-7163.MCT-15-0201-T
Vamsee Krishna Chatakonda, Hua Shi, Daiying Xu, Aptamer modulators of estrogen receptors ,(2012)
Lee Adam Wheeler, Radiana Trifonova, Vladimir Vrbanac, Emre Basar, Shannon McKernan, Zhan Xu, Edward Seung, Maud Deruaz, Tim Dudek, Jon Ivar Einarsson, Linda Yang, Todd M. Allen, Andrew D. Luster, Andrew M. Tager, Derek M. Dykxhoorn, Judy Lieberman, Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras Journal of Clinical Investigation. ,vol. 121, pp. 2401- 2412 ,(2011) , 10.1172/JCI45876
Brian P Fox, Raj P Kandpal, Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application. Biochemical and Biophysical Research Communications. ,vol. 318, pp. 882- 892 ,(2004) , 10.1016/J.BBRC.2004.04.102
James O. McNamara, Despina Kolonias, Fernando Pastor, Robert S. Mittler, Lieping Chen, Paloma H. Giangrande, Bruce Sullenger, Eli Gilboa, Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice Journal of Clinical Investigation. ,vol. 118, pp. 376- 386 ,(2008) , 10.1172/JCI33365