Aptamers and uses thereof

作者: David Spetzler , Tassilo Hornung , Valeriy Domenyuk , Frank Schafer , David Halbert

DOI:

关键词: MicrovesicleAptamerComputational biologyMolecular biologyBiology

摘要: Methods and compositions are provided for specific aptamers aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments antigens. In various embodiments, the invention used in diagnostic, prognostic, theranostic processes to screen a biological sample presence levels micro vesicles determined provide readout. The diagnosis, prognosis, theranosis may be related cancer other diseases disorders. also provides methods composition facilitate library screening detection methods.

参考文章(387)
Hanna G. Budayeva, Ileana M. Cristea, A Mass Spectrometry View of Stable and Transient Protein Interactions Advances in Experimental Medicine and Biology. ,vol. 806, pp. 263- 282 ,(2014) , 10.1007/978-3-319-06068-2_11
David Spetzler, Tassilo Hornung, Valeriy Domenyuk, Michael Famulok, Günter Mayer, Compositions and methods for aptamer screening ,(2013)
M. Unger, E. Kartalov, C.-S. Chiu, H.A. Lester, S.R. Quake, Single-molecule fluorescence observed with mercury lamp illumination. BioTechniques. ,vol. 27, pp. 1008- 1014 ,(1999) , 10.2144/99275RR01
Takahisa Ibii, Satoru Hatakeyama, Method for screening nucleic acid ligand ,(2011)
Christine Kuslich, David Spetzler, Traci Pawlowski, Dectection of gastrointestinal disorders ,(2011)