Synthesis, growth inhibition, and cell cycle evaluations of novel flavonoid derivatives
作者： Yerra Koteswara Rao , Shih-Hua Fang , Yew-Min Tzeng
DOI: 10.1016/J.BMC.2005.07.062
关键词:
摘要: As a continuation of our search for potential new anticancer agents, series ten flavonoid derivatives has been synthesized by cyclization substituted chalcones. Target compounds were evaluated their biological activity. Among them, 1-4 and 9 displayed significant growth inhibitory action against panel tumor cell lines including Jurkat, PC-3, Colon 205. On treatment with an equitoxic (IC50) concentration, 1-5 7-9 blocked cells in the G2/M phase Jurkat cycle, whereas compound 6 same G0/G1 phase.
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