Effects of stress and of amphetamine on passive avoidance conditioning in rats.

摘要: This study examined the effects of immobilization stress combined with water immersion (ICS) and/or amphetamine (AM) on different memory phases in passive avoidance task rats. The performance rats was evaluated retention tests 24 and 48 h after a single acquisition trial. ICS exposure lasting 1 impaired learned response if applied 2 to 4 before or immediately training. stressor did not affect retrieval presented 5 test. AM used i.p. at dose 8 mg/kg. Neither mg administered nor doses given training impair unstressed prevented impairment animals exposed 3 but had no effect when stronger induced by However, testing, attenuated even severe pre-training exposure. Our results suggest that impairs primarily early phase consolidation low can prevent this effect.