Misoprostol is more efficacious for labor induction than prostaglandin E2, but is it associated with more risk?

摘要: Abstract Objective: Our purpose was to compare the efficacy and safety of misoprostol with dinoprostone (Prepidil) for labor induction. Study Design: In a randomized, controlled trial induction, patients were randomly assigned receive either 50 μg intravaginal every 4 hours or 0.5 mg intracervical prostaglandin E 2 6 hours. Eligibility criteria included gestation ≥31 weeks, Bishop score Results: One hundred fifty-nine women (n = 81) Prepidil 78). There no differences in indication preinduction score, epidural use, cesarean section rate. Mean time delivery significantly shorter group (19 minutes) than (28 52 ( P .005). Only 58% required oxytocin augmentation, comparison 88% receiving .00002). However, 41% 17% had late decelerations bradycardias .001), 20% 5% deliveries fetal distress .05). Conclusions: Misoprostol is more efficacious increased incidence abnormal heart rate tracings trend dosing are concern. These data suggest that lower dose less frequent should be considered. (Am J Obstet Gynecol 1999;180:1543-50.)