摘要: Publisher Summary This chapter reviews the pathophysiology of loosening replacement joints where these are considered to be related biological cellular mechanisms. Infection in a replaced joint is major cause for concern. The diagnosis infection might straightforward many cases but criteria reaching such not yet agreed. describes part played by radiology, blood tests and microbiology discusses usefulness histopathological examination tissue. Aseptic far most common reason revision total has been considered. There various non-biological factors that contribute to, or even main culprits in, any particular case, there undoubtedly significant contribution made wear debris reaction this implant bed. involvement phagocytic cells dealing with foreign material described likely interactions lymphocytes, which may give rise an immunologically mediated process, discussed. recognizable processes prosthetic failure pain loosening, some presence microorganisms, mechanical effects others particles.
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