Thienopyrimidine inhibitors of atypical protein kinase c
作者： Keith S. Learn , Bruce D. Dorsey , Christelle N. Soudy , Jason C. Wagner , Emma L. Morris
DOI:
关键词:
摘要: The present invention provides a compound of formula (I) or salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A its salts have PKC inhibitory activity, may be used to treat proliferative disorders.
lens.org 参考文章(53)
Alfonso R. Gennaro, Remington: The Science and Practice of Pharmacy ,(2003)
Shamal A Mehta, Hitesh K Patel, Andiliy G Lai, Robert M Grotzfeld, Zdravko V Milanov, David J Lockhart, Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases ,(2005)
Changgeng Qian, Rudi Bao, Chengjung Lai, Treatment of cancers having k-ras mutations ,(2011)
Richard C. Larock, Comprehensive organic transformations : a guide to functional group preparations Wiley-VCH. ,(2018) , 10.1002/9781118662083
László Kürti, Barbara Czakó, K. C. Nicolaou, E. J. Corey, Strategic Applications of Named Reactions in Organic Synthesis: Background and Detailed Mechanisms ,(2005)
Juan Jose Vaquero Lopez, Jose Miguel Minguez Ortega, Julio Alvarez-Builla Gomez, Emma Terricabras Belart, Victor Manuel Segarra Matamoros, 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives as PDE7 inhibitors ,(2004)
Hiroyuki Kaizawa, Hiroyuki Moritomo, Mayumi Yamano, Tomonobu Koizumi, Mitsuaki Ohta, Ken-Ichi Kawaguchi, Masahiko Hayakawa, Minoru Okada, Koyo Matsuda, Condensed heteroaryl derivatives ,(2001)
Haixiao Zhai, Xiong Cai, Cheng-Jung Lai, Changgeng Qian, Phosphoinositide 3-kinase inhibitors with a zinc binding moiety ,(2010)
Marion W. Wannamaker, Robert J. Davies, Deborah Choquette, Pyrimidine-based compounds useful as gsk-3 inhibitors ,(2002)
Peter Parker, Michael Waterfield, Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents ,(2003)