Intravenous pulse methylprednisolone followed by alternate day corticosteroid therapy in lupus erythematosus: a prospective evaluation

摘要: We explored the feasibility of using intravenous pulse methylprednisolone followed by alternate day steroids for treatment active systemic lupus erythematosus (SLE) in an attempt to avoid longterm daily steroid therapy. Our study was terminated after 11 trials because sustained control disease activity possible only a minority patients. Pulse therapy initially very effective: there rapid improvement clinical symptoms, and significant serum anti-DNA (p less than .01) C3 .05), but not other laboratory tests, within 2 weeks treatment. On followup, had be discontinued 7 trials; 3 patients experienced recurrence their presenting 4 demonstrated worsening abnormalities reflective renal disease. Despite efficacy initial management SLE, could successfully maintained on subsequent regimen prolonged periods.