Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
作者： Mark G. P. Saifer , Alexa L. Martinez , L. David Williams , Merry R. Sherman
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摘要: Methods are provided for the preparation of conjugates a variety bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof), which have reduced antigenicity immunogenicity compared to similar prepared using containing methoxyl or another alkoxyl group. The invention also provides by such methods, compositions comprising conjugates, kits methods use in diagnostic therapeutic protocols.
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