An insulin conjugate using an immunoglobulin fragment
作者： Se Chang Kwon , Dae Hae Song , Young Jin Park , Jae Hee Hee Shin , Sung Min Bae
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摘要: The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking with immunoglobulin Fc region via a non-peptidyl polymer, long-acting formulation comprising the same, preparation method thereof. of maintains activity peptide at relatively high level remarkably increases serum half-life thereof, thereby greatly improving drug compliance upon treatment.
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