Peg linker compounds and biologically active conjugates thereof
作者： Chyi Lee
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摘要: PEG linker compounds and biologically active conjugates thereof having mixed functional group linkages attached to at least one moeity, a coupling for attaching molecule. The can be the combinations of stable, or labile, releasable, stable releasable labile covalent linkages. consist different organic groups, which have non-equivalent half-life in plasma and, hence, they release rates blood. present invention also provides attachment novel with Pegylation molecules produce Probiomolecule-PEG constructs. construct is prodrug biomolecule-PEG conjugate biomolecule. will gradually lose portions (or all) its polymers vivo convert into smaller size molecule), thereby increasing their biological activity vivo.
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