Synthesis of isoascididemin, a regioisomer of the marine alkaloid ascididemin

作者: Enrique Gomez-Bengoa , Antonio M. Echavarren

DOI: 10.1021/JO00011A011

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摘要: The synthesis of isoascididemin, a regioisomer the naturally occurring ascididemin, has been completed in nine steps from 2,5-dimethoxyaniline. key feature selective palladium(0)-catalyzed cross-coupling reaction 6-bromo-5,8-dimethoxy-4-[(trifluoromethanesulfonyl)oxy] quinoline with N-(tert-butoxycarbonyl)-2-(trimethylstannyl)aniline promoted by Cu(I) and hetero-Dields-Alder quinoline-5,8-dione acrolein N,N-dimethylhydrazone

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