Bone Matrix Proteoglycans in Skeletal Function
作者： Vardit Kram , Marian F. Young
DOI: 10.1016/B978-0-12-397165-4.00008-3
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摘要: Proteoglycans (PGs) are a widely diverse family of macromolecules copiously found on cell membranes and in the (ECM) many tissues throughout musculoskeletal system. Structurally, these composed protein core to which several linear glycosaminoglycan (GAG) side chains covalently bound. As PGs usually extracellular or bound cellular they play role maintaining structural integrity, including, for example, collagen fibrillogenesis. In addition, as GAG able bind multitude surface receptors, cytokines growth factors, act both local reservoir factors well upstream mediators cell-signaling pathways. Animal studies indicate that manipulating expression different has profound effect system cases generated animal models with traits resemble osteogenesis imperfecta.
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