Acquiring Chondrocyte Phenotype from Human Mesenchymal Stem Cells under Inflammatory Conditions

摘要: An inflammatory milieu breaks down the cartilage matrix and induces chondrocyte apoptosis, resulting in destruction patients with degenerative diseases, such as rheumatoid arthritis or osteoarthritis. Because of limited regenerative ability chondrocytes, defects are irreversible difficult to repair. Mesenchymal stem cells (MSCs) expected be a new tool for repair because they present able differentiate into multiple lineages cells, including chondrocytes. Although clinical trials using MSCs have already begun, its efficacy mechanisms remain unknown. A PubMed search conducted October 2014 following medical subject headings (MeSH) terms: mesenchymal stromal chondrogenesis, cytokines resulted 204 articles. The titles abstracts were screened nine articles relevant “inflammatory” “human” identified. Herein, we review cell biology phenotype acquisition from human an discuss potential