Consequences of universal MSI/IHC in screening ENDOMETRIAL cancer patients for lynch syndrome
作者： Bojana Djordjevic , Rajyalakshmi Luthra , Bryan M. Fellman , Karen H. Lu , Russell R. Broaddus
DOI: 10.1016/J.YGYNO.2014.06.009
关键词:
摘要: Objective Determine factors impacting the uptake of genetic counseling and results of genetic testing following universal tumor testing for Lynch syndrome in patients with endometrial cancer. Methods The study population consisted of two unselected cohorts of endometrial cancer patients, 408 identified retrospectively and 206 identified prospectively. Immunohistochemistry for mismatch repair protein expression and/or microsatellite instability analysis was performed on these tumors. MLH1 methylation analysis was performed on …
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Deanna S. Cross, , Alanna Kulchak Rahm, Tia L. Kauffman, Jennifer Webster, Anh Quynh Le, Heather Spencer Feigelson, Gwen Alexander, Paul Meier, Adedayo A. Onitilo, Pamala A. Pawloski, Andrew E. Williams, Stacey Honda, YeeHwa Daida, Catherine A. McCarty, Katrina A.B. Goddard, Underutilization of Lynch syndrome screening in a multisite study of patients with colorectal cancer Genetics in Medicine. ,vol. 15, pp. 933- 940 ,(2013) , 10.1038/GIM.2013.43
María Rodríguez–Soler, Lucía Pérez–Carbonell, Carla Guarinos, Pedro Zapater, Adela Castillejo, Victor M Barberá, Miriam Juárez, Xavier Bessa, Rosa M Xicola, Juan Clofent, Luis Bujanda, Francesc Balaguer, Josep–Maria Reñé, Luisa de–Castro, José C Marín–Gabriel, Angel Lanas, Joaquín Cubiella, David Nicolás–Pérez, Alejandro Brea–Fernández, Sergi Castellví–Bel, Cristina Alenda, Clara Ruiz–Ponte, Angel Carracedo, Antoni Castells, Montserrat Andreu, Xavier Llor, José L Soto, Artemio Payá, Rodrigo Jover, None, Risk of cancer in cases of suspected lynch syndrome without germline mutation. Gastroenterology. ,vol. 144, pp. 926- 932 ,(2013) , 10.1053/J.GASTRO.2013.01.044
J LANCASTER, C BETHANPOWELL, N KAUFF, I CASS, L CHEN, K LU, D MUTCH, A BERCHUCK, B KARLAN, T HERZOG, Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. Gynecologic Oncology. ,vol. 107, pp. 159- 162 ,(2007) , 10.1016/J.YGYNO.2007.09.031
Christopher D South, Martha Yearsley, Edward Martin, Mark Arnold, Wendy Frankel, Heather Hampel, Immunohistochemistry staining for the mismatch repair proteins in the clinical care of patients with colorectal cancer Genetics in Medicine. ,vol. 11, pp. 812- 817 ,(2009) , 10.1097/GIM.0B013E3181B99B75
Paul Ryan, Anna Marie Mulligan, Melyssa Aronson, Sarah E. Ferguson, Bharati Bapat, Kara Semotiuk, Spring Holter, Janice Kwon, Steve E. Kalloger, C. Blake Gilks, Steven Gallinger, Aaron Pollett, Blaise A. Clarke, Comparison of clinical schemas and morphologic features in predicting Lynch syndrome in mutation‐positive patients with endometrial cancer encountered in the context of familial gastrointestinal cancer registries Cancer. ,vol. 118, pp. 681- 688 ,(2012) , 10.1002/CNCR.26323
MJ Esplen, L Madlensky, M Aronson, H Rothenmund, S Gallinger, K Butler, B Toner, J Wong, M Manno, J McLaughlin, Colorectal cancer survivors undergoing genetic testing for hereditary non-polyposis colorectal cancer: motivational factors and psychosocial functioning. Clinical Genetics. ,vol. 72, pp. 394- 401 ,(2007) , 10.1111/J.1399-0004.2007.00893.X
Floor J. Backes, Marino E. Leon, Iouri Ivanov, Adrian Suarez, Wendy L. Frankel, Heather Hampel, Jeffrey M. Fowler, Larry J. Copeland, David M. O'Malley, David E. Cohn, Prospective evaluation of DNA mismatch repair protein expression in primary endometrial cancer Gynecologic Oncology. ,vol. 114, pp. 486- 490 ,(2009) , 10.1016/J.YGYNO.2009.05.026
Sally W. Vernon, Ellen R. Gritz, Susan K. Peterson, Christopher I. Amos, Catherine A. Perz, Walter F. Baile, Patrick M. Lynch, Correlates of Psychologic Distress in Colorectal Cancer Patients Undergoing Genetic Testing for Hereditary Colon Cancer Health Psychology. ,vol. 16, pp. 73- 86 ,(1997) , 10.1037/0278-6133.16.1.73
Nicky Dekker, Eleonora B. L. van Dorst, Rob B. van der Luijt, Marielle E. van Gijn, Marc van Tuil, Johan A. Offerhaus, Margreet G. E. M. Ausems, Acceptance of Genetic Counseling and Testing in a Hospital-Based Series of Patients with Gynecological Cancer Journal of Genetic Counseling. ,vol. 22, pp. 345- 357 ,(2013) , 10.1007/S10897-012-9553-3
Arjen R. Mensenkamp, Ingrid P. Vogelaar, Wendy A.G. van Zelst–Stams, Monique Goossens, Hicham Ouchene, Sandra J.B. Hendriks–Cornelissen, Michael P. Kwint, Nicoline Hoogerbrugge, Iris D. Nagtegaal, Marjolijn J.L. Ligtenberg, Somatic Mutations in MLH1 and MSH2 Are a Frequent Cause of Mismatch-Repair Deficiency in Lynch Syndrome-Like Tumors Gastroenterology. ,vol. 146, pp. 643- 646 ,(2014) , 10.1053/J.GASTRO.2013.12.002