Autres biomarqueurs potentiels des anti-EGFR

作者: F. Di Fiore , P. Michel

DOI: 10.1007/978-2-8178-0527-6_13

关键词:

摘要: Les deux dates les plus marquantes dans la prise en charge du cancer colo-rectal (CCR) ces dernieres annees ont sans doute ete 2004 et 2006. L’annee a ainsi un veritable tournant CCR car elle marquee conjointement par l’avenement FOLFOX le traitement adjuvanThet l’emergence des therapies ciblees anti-VEGF (ou Vascular Endothelial Growth Factor) anti-EGFR Epidermal Factor Receptor) l’arsenal therapeutique me- tastatique [1–3]. 2006 celle de l’entree tres remarquee ciblage metastatique avec recherche mutations KRAS comme marqueur resistance aux [4]. Actuellement, quelques 6 recul eThen depit d’avancees significatives au plan nombreux axes developpes niveau recherche, calendrier est moins flamboyant. En effet, aucun autre biomarqueur ou sensibilite n’a valide quete d’un ideal biotherapies reste l’un enjeux majeurs discipline.

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