Usefulness of procalcitonin for differentiation between activity of systemic autoimmune disease (systemic lupus erythematosus/systemic antineutrophil cytoplasmic antibody-associated vasculitis) and invasive bacterial infection
作者： M. Haubitz , F. M. Brunkhorst , V. Kliem , K. M. Koch , R. Brunkhorst
DOI: 10.1002/1529-0131(199707)40:7<1250::AID-ART9>3.0.CO;2-A
关键词:
摘要: Objective. To investigate whether the determination of serum procalcitonin (PCT) in systemic autoimmune disease will help to discriminate invasive infection from highly active underlying disease. Methods. Three hundred ninety-seven samples, 18 patients with lupus erythematosus (SLE) and 35 antineutrophil cytoplasmic antibody-associated vasculitis (AAV), were analyzed. Clinical activity was assessed by Systemic Lupus Activity Measure SLE Birmingham Vasculitis Score AAV patients. Procalcitonin concentrations determined parallel neopterin, interleukin-6 (IL-6), C-reactive protein (CRP). Additionally, creatinine values obtained. Results. In 321 324 samples 42 but without infection, PCT levels within normal range (i.e., <0.5 ng/ml), whereas for IL-6, CRP elevated disease. All 16 infections occurred 11 AAV, associated that markedly elevated, a mean ± SD 1.93 1.19 ng/ml. No correlation between degree renal impairment seen. Conclusion. may serve as useful marker detection bacterial
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