Study of the Validity of Neutrophil CD64 and Serum Procalcitonin as Diagnostic Markers to Discriminate Infection from Disease Activity in Patients with Systemic Lupus Erythematosus

摘要: Introduction: In addition to the complexity of clinical presentation both infections and disease activity in systemic lupus erythematosus (SLE) patients, difficulty making therapeutic decision require investigations that should be diagnostic value. Neutrophil CD64 is up regulated within few hours patients with infection. Similarly, serum procalcitonin (PCT) levels increase rapidly following bacterial Objective: The aim this work study usefulness neutrophil expression PCT as markers discriminate infection from erythematosus. Methods: This was carried on 20 healthy females controls (group I) 55 female SLE. Patients were distributed following; SLE without or II), III), 15 IV). CBC, ANA, Anti-ds DNA, C3 C4 measured all population. Serum by ELFA done flowcytometry. Results: increased significantly compared those activity. We demonstrated significant correlations between infection, while correlated area under ROC curves for detection (AUC; 95% CI) (0.90; 0.79-1.01) (0.99; 0.95-1.01), respectively. Conclusion: Our findings can prove are reliable patients. more accurate than expression.