Single-Cell Electrophysiology and Ion Channelopathies

摘要: The electrical behavior of the heart reflects interactions among highly specialized and tightly regulated excitable cells. Control membrane potential at rest during action organizes rhythmic activity pacemaker regions heart, thereby determining sequence activation through myocardium that leads to cyclical contraction relaxation. electrophysiological properties individual myocytes are determined by myriad ion channels electrogenic pumps pass current across sarcolemma. function these proteins can be altered a variety neurotransmitters, neurohormones, drugs. In addition, changes in their surface density or functional have profound effects on excitability, risk arrhythmias, mechanical function. Examination cardiac regulation is key understanding excitability normal pathological states mechanisms underlying drug heart.