MR volumetric assessment of endolymphatic hydrops.

摘要: We aimed to volumetrically quantify endolymph and perilymph spaces of the inner ear in order establish a methodological basis for further investigations into pathophysiology therapeutic monitoring Meniere’s disease. Sixteen patients (eight females, aged 38–71 years) with definite unilateral disease were included this study. Magnetic resonance (MR) cisternography T2-SPACE sequence was combined Real reconstruction inversion recovery (Real-IR) delineation fluid spaces. Machine learning automated local thresholding segmentation algorithms applied three-dimensional (3D) volumetric quantification endolymphatic hydrops. Test–retest reliability assessed by intra-class coefficient; correlation cochlear volume ratio hearing function Pearson coefficient. Endolymph ratios could be reliably measured all patients, mean (range) value 15 % (2–25) cochlea 28 % (12–40) vestibulum. Test-retest excellent, an coefficient 0.99. Cochlear hydrops significantly correlated loss (r = 0.747, p = 0.001). MR imaging after contrast application image processing, including machine thresholding, enable This allows quantitative assessment effect interventions on • Endolymphatic is pathological hallmark disease. can visualized locally enhanced ultra-high-resolution imaging. Computer-aided processing enables hydrops. correlates Therapeutic trials monitored approach.