Randomized, prospective, controlled study comparing radical prostatectomy alone and neoadjuvant androgen withdrawal in the treatment of localized prostate cancer
作者： S. Larry Goldenberg , Laurence H. Klotz , John Srigley , Michael A.S. Jewett , David Mador
DOI: 10.1016/S0022-5347(01)65645-3
关键词:
摘要: AbstractPurpose: A prospective, multicenter, randomized study was done to test the hypothesis that neoadjuvant androgen withdrawal decreases incidence of positive margins following radical prostatectomy for localized prostate cancer.Materials and Methods: Observations were made 213 patients undergo alone (101) or receive a 12-week course 300 mg. cyproterone acetate daily followed by surgery (112). Groups similar at baseline in terms clinical stage, serum specific antigen Gleason score. Of 192 available efficacy analysis 9 had stage T1b, 8 T1c, 63 T2a, 36 T2b 76 T2c disease.Results: One more surgical found 59 91 (64.8 percent) only group compared 28 101 (27.7 (p = 0.001). Patients who received preoperative therapy statistically significantly lower rate apical margin involvement than thos...
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