Structural insights into N-linked glycan-mediated protein folding from chemical and biological perspectives.
作者： Taiki Kuribara , Kiichiro Totani
DOI: 10.1016/J.SBI.2020.11.004
关键词:
摘要: About half of all newly synthesized proteins have N-linked glycans. These glycans play pivotal roles in controlling the folding, sorting, and degradation glycoproteins via several glycan-related proteins. The glycan-mediated protein quality control system is important for cellular homeostasis. In this review, we summarize recent advances our understanding discuss structural insights from chemical biological perspectives. particular, focus on mechanisms by which these mediators respond to folding states glycoproteins.
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