Intracellular lectins are involved in quality control of glycoproteins.
作者： Kazuo YAMAMOTO
DOI: 10.2183/PJAB.90.67
关键词:
摘要: Glycoprotein quality control is categorized into three kinds of reactions; the folding nascent glycoproteins, ER-associated degradation misfolded or unassembled and transport sorting correctly folded glycoproteins. In all processes, N-glycans on glycoproteins are used as tags that recognized by intracellular lectins. We analyzed functions these lectins their sugar-binding specificities. The results clearly showed A, B, C-arms high mannose-type glycans participate in folding, sorting, degradation, respectively, newly synthesized peptides. After transported to Golgi apparatus, trimmed Man3GlcNAc2 then rebuilt various complex-type Golgi, resulting addition diverse sugar structures allow play roles outside cells.
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