The Vascularization of Experimental and Human Primary Tumors: Comparative Morphometric and Morphologic Studies

摘要: The importance of the blood vessel system in solid tumors has given rise to an increasing interest this as a direct target for tumor therapy, i.e. vascular targeting (Denekamp, 1984). Furthermore, its route delivery anticancer drugs (chemo- and immunotherapies) or photosensitizers (photodynamic laser therapy), well modulatory influences on radiotherapy hyperthermia — former greatly depending amount oxygen available, latter heat transfer are evident. Numerous studies energy metabolism (Vaupel et al., 1987, 1989) have pointed out functional stress need further thorough investigations functions terms transport capacities nutrients, oxygen, catabolite removal, therapeutic substances, transfer.