The Role of Epidermal Growth Factor Receptor in the Initiation and Progression of Malignancy
作者： K. Khazaie
DOI: 10.1007/978-3-662-03391-3_9
关键词:
摘要: Sequence homologies between the cellular platelet-derived growth factor (PDGF) and epidermal receptor (EGFR) with theproducts of retroviral simian sarcoma virus (SSV) v-sis (Doolittle et al. 1984; Waterfield 1983) avian erythroblastosis (AEV) v-erbB (Downward 1984b) putative oncogenes provided strong support for notion that deregulation control may form basis cancer. This was practically demonstrated in case by functional replacement through human EGFR (Khazaie 1988). Oncogenes cell proliferation a powerful tool explaining cancer at molecular level (Sinn 1987).
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