Miliary Never-Smoking Adenocarcinoma of the Lung: Strong Association with Epidermal Growth Factor Receptor Exon 19 Deletion

摘要: Miliary pattern of pulmonary metastases is a rarity in patients with lung cancer. We report five cases never-smoking adenocarcinoma the such metastases. In tumor cells all patients, epidermal growth factor receptor (EGFR) mutation gene sequencing identified deletion exon 19 EGFR gene, and had dramatic response to tyrosine kinase inhibitors. No echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma (ALK) translocation was detected. believe that miliary never-soking distinct clinically relevant subgroup non-small cell Physician should recognize this cancer when facing picture chest x-ray or computed tomography scan history never smoking consider upfront therapy