Nuclear Architecture, Chromosome Aberrations, and Genetic Damage
作者： Gustavo A. Folle , María Vittoria Di Tomaso , Laura Lafon-Hughes , Pablo Liddle
DOI: 10.1007/978-1-4614-6558-4_3
关键词:
摘要: Mammalian interphase nuclei are highly organized structures in which chromosome territories nonrandomly distributed following a radial pattern. Gene richness and size markedly influence nuclear positioning. Active euchromatin inactive heterochromatin exhibit different topology: the former is centrally located latter mostly placed at periphery, within chromocenters, around nucleoli. DNA subjected to wide repertoire of insults including radiation, chemical, biological agents. The differential sensitivity clastogens has been matter debate, although most experimental evidence supports that more damage prone. expression synthesis coupled chromatin remodeling could act as key factors distribution aberrations (CA) euchromatic heterochromatic regions genome. In this chapter, main features architecture well an overview current knowledge genetic metaphase levels presented. Also, preferential involvement transcriptionally active human genome regarding induction deregulation tumor genes analyzed. Finally, impact replication timing connected processes generation localization CA primary discussed.
springer.com
sci-hub.st 参考文章(60)
W Martinez-Lopez, GA Folle, G Obe, P Jeppesen, Chromosome regions enriched in hyperacetylated histone H4 are preferred sites for endonuclease- and radiation-induced breakpoints. Chromosome Research. ,vol. 9, pp. 69- 75 ,(2001) , 10.1023/A:1026747801728
Felix A. Habermann, Marion Cremer, Joachim Walter, Gregor Kreth, Johann von Hase, Karin Bauer, Johannes Wienberg, Christoph Cremer, Thomas Cremer, Irina Solovei, Arrangements of macro- and microchromosomes in chicken cells. Chromosome Research. ,vol. 9, pp. 569- 584 ,(2001) , 10.1023/A:1012447318535
Abdel Aouacheria, Vincent Navratil, Audrey Barthelaix, Dominique Mouchiroud, Christian Gautier, Bioinformatic screening of human ESTs for differentially expressed genes in normal and tumor tissues. BMC Genomics. ,vol. 7, pp. 94- 94 ,(2006) , 10.1186/1471-2164-7-94
Michaël Gué, Jian-Sheng Sun, Thomas Boudier, Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited BMC Cancer. ,vol. 6, pp. 20- 20 ,(2006) , 10.1186/1471-2407-6-20
M. GRIGOROVA R. BRAND Y. XIAO A. T. NA, Frequencies and types of exchange aberrations induced by X-rays and neutrons in Chinese hamster splenocytes detected by FISH using chromosome-specific DNA libraries. International Journal of Radiation Biology. ,vol. 74, pp. 297- 314 ,(1998) , 10.1080/095530098141447
G P Holmquist, Chromosome bands, their chromatin flavors, and their functional features. American Journal of Human Genetics. ,vol. 51, pp. 17- 37 ,(1992)
Irina Solovei, Moritz Kreysing, Christian Lanctôt, Süleyman Kösem, Leo Peichl, Thomas Cremer, Jochen Guck, Boris Joffe, Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution Cell. ,vol. 137, pp. 356- 368 ,(2009) , 10.1016/J.CELL.2009.01.052
L. Harewood, F. Schutz, S. Boyle, P. Perry, M. Delorenzi, W. A. Bickmore, A. Reymond, The effect of translocation-induced nuclear reorganization on gene expression Genome Research. ,vol. 20, pp. 554- 564 ,(2010) , 10.1101/GR.103622.109
B. Jakob, J. Splinter, M. Durante, G. Taucher-Scholz, Live cell microscopy analysis of radiation-induced DNA double-strand break motion Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 3172- 3177 ,(2009) , 10.1073/PNAS.0810987106
Nicolas Sadoni, Sabine Langer, Christine Fauth, Giorgio Bernardi, Thomas Cremer, Bryan M. Turner, Daniele Zink, Nuclear organization of mammalian genomes : Polar chromosome territories build up functionally distinct higher order compartments Journal of Cell Biology. ,vol. 146, pp. 1211- 1226 ,(1999) , 10.1083/JCB.146.6.1211