CD4 Intragenic SNPs Associate With HIV-2 Plasma Viral Load and CD4 Count in a Community-Based Study From Guinea-Bissau, West Africa

摘要: Objectives: The human genetics of HIV-2 infection and disease progression is understudied. Therefore, we studied the effect variation in 2 genes that encode products critical to HIV pathogenesis progression: CD4 CD209. Design: This cross-sectional study consisted 143 HIV-2, 30 HIV-1 + 29 HIV-1-infected subjects 194 uninfected controls recruited from rural Guinea-Bissau. Methods: We genotyped 14 4 CD209 single nucleotide polymorphisms (SNPs) were tested for association with infection, plasma viral load (high vs. low), CD4+ T-cell count low). Results: most significant was between a haplotype rs11575097-rs10849523 high [odds ratio (OR): = 2.37, 95% confidence interval (CI): 1.35 4.19, P 0.001, corrected multiple testing], suggesting increased genetic susceptibility individuals carrying high-risk haplotype. Significant associations also observed at SNP (rs2255301) (OR: 2.36, CI: 1.19 4.65, 0.01) any 2.50, 1.34 4.69, 0.004). Conclusions: Our results support role agreement recent data showing gene variants increase risk Kenyan female sex workers. These findings indicate least some commonality susceptibility.