Platelets from stem cells

作者: James A. Thomson , Dong Chen

DOI:

关键词:

摘要: Human embryonic stem cells are induced to differentiate first into the hematopoietic lineage and then megakaryocytes, which generate platelets. The proper in vitro culture of megakaryocytes results production shed This makes possible, for time, a human blood factor needed by many patients.

参考文章(29)
R Guerriero, U Testa, M Gabbianelli, G Mattia, E Montesoro, G Macioce, A Pace, B Ziegler, HJ Hassan, C Peschle, Unilineage megakaryocytic proliferation and differentiation of purified hematopoietic progenitors in serum-free liquid culture. Blood. ,vol. 86, pp. 3725- 3736 ,(1995) , 10.1182/BLOOD.V86.10.3725.BLOODJOURNAL86103725
Andrew George Elefanty, Stephen Anthony Livesey, Edouard Guy Stanley, Elizabeth Siewsun Stadler, Methods for producing blood products from pluripotent cells in cell culture ,(2004)
Michael F. Clarke, Stephen G. Emerson, R. Douglas Armstrong, Bernhard O. Palsson, Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture ,(1994)
M Ogura, Y Morishima, R Ohno, Y Kato, N Hirabayashi, H Nagura, H Saito, Establishment of a Novel Human Megakaryoblastic Leukemia Cell Line, MEG-01, With Positive Philadelphia Chromosome Blood. ,vol. 66, pp. 1384- 1392 ,(1985) , 10.1182/BLOOD.V66.6.1384.1384
James A. Thomson, Vivienne S. Marshall, Primate embryonic stem cells Current Topics in Developmental Biology. ,vol. 38, pp. 133- 165 ,(1996) , 10.1016/S0070-2153(08)60246-X
Elisabeth Battinelli, Joseph Loscalzo, Nitric oxide induces apoptosis in megakaryocytic cell lines Blood. ,vol. 95, pp. 3451- 3459 ,(2000) , 10.1182/BLOOD.V95.11.3451
Barbara W. Grant, Kenneth G. Mann, Megakaryocyte growth promoting activity protein ,(1990)