Engineered alignment in media equivalents: magnetic prealignment and mandrel compaction.
作者： V. H. Barocas , T. S. Girton , R. T. Tranquillo
DOI: 10.1115/1.2834759
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摘要: We predicted and measured the evolution of smooth muscle cell (SMC) orientation in media-equivalents (MEs) for four fabrication conditions (F-, M-, F+, M+) under Free or Mandrel compaction (F/M) with without magnetic prealignment collagen fibrils circumferential direction (+/-). refers to SMC-induced ME that is constrained by having a nonadhesive mandrel placed lumen. Predictions were made using our anisotropic biphasic theory (ABT) tissue-equivalent mechanics. Successful prediction trends SMC data all cases was obtained: maintenance initial isotropic state F-, loss alignment development enhancement M+. These results suggest two mechanisms which presence leads much greater mechanical stiffness reported compacted MEs relative free MEs: (1) inducing an increasing collagen, (2) large stress on SMC, resulting secretion accumulation stiffening components.
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