Induction of Malignant Transformation in Hamster Fetal Cells (HFC) by Diverse Environmental Carcinogens

摘要: Toxicity of environmental agents, more specifically cancer risk, is important for estimating the human health risk associated with exposure to substances present in foods, drugs, consumer products and industrial environments. Epidemiologic studies as summarized by IACR incriminate 23 chemicals carcinogens (1). These correlate long term animal carcinogenesis studies. For several chemicals, aflatoxin B1, 4-aminobiphenyl, bis(chloromethyl) ether, diethylstilbesterol, mustard gas, vinyl chloride, predated epidemiologic evidence. Concentration duration are effect on humans. Results indicate that protracted a weak carcinogen may be just deleterious pulse potent carcinogen, factors must evaluated making regulatory decision based predictive tests.