Prognostic value of measurements of angiogenesis in serous carcinoma of the ovary.

摘要: The study objective was to determine whether tumor vascularity correlates with patient survival, compare newer semiautomated methods of angiogenesis assessment older methods, and if advanced image analysis can offer useful outcome data in serous ovarian cancer. Using the specific endothelial marker CD34, microvessel determinations were quantified 132 tumors by manual counting at final magnifications x200 x400 most highly vascular areas. Computer-assisted counts, area estimates, minimum spanning tree (MST) capillary architecture, which involves intercapillary distances, correlated traditional techniques. Manual, semiautomated, found be reproducible express strong correlation one another. Univariate cyclooxygenase revealed parameters significant predictors for overall survival (OS) disease-free survival. Multivariate maximum MST (P = 0.009), length 0.005), 1 nearest neighbor <= 0.01) mean density (x400) 0.0001) OS, stage 0.001) Despite showing prognostic significance on univariate analysis, clinicopathologic did not retain independent multivariate analysis. Microvessel determination is an indicator patients carcinoma. a method capable accurately evaluating vascularity. Minimum architecture strongest prognosticator suggesting this promising marker.