Prognostic significance of tumour vascularisation on survival of patients with advanced ovarian carcinoma

摘要: Summary. Objective. The prognostic significance of microvessel density in ovarian cancer is still a matter debate. Classically, the degree vascularisation assessed areas high vascular (hot spots), considered as regions increased probability metastasis. Since tumours have particular progression and dissemination behaviour, outside hot spots may also contribute to their evolution. Methods. In present study, tumour was estimated both whole histogical sections spots, 235 patients with carcinoma, using fully automatic image analysis methods. Six parameters were estimated: mean (MVD) surface fraction (MSP) on section, maximum values MVD MSP inside (MVDHS1, MSPHS1 MVDHS2, MSPHS2). Relationships between clinicopathologic features analysed. Results. stage III-IV multivariate showed that IV disease (hazards ratio (HR)=1.72, p=0.001), post-surgical residual 1cm (HR=2.86, p<0.001), upper tercile (HR=1.45, p<0.022) medial MVDHS1 (HR=1.36, p=0.060) retained an independent value upon overall survival. Conclusion. Our results suggest quantification blood vessels, histological section might be helpful evaluating prognosis advanced carcinomas.