Correlation between tumor suppressor inhibitor of growth family member 4 expression and microvessel density in breast cancer.
作者： Liangyu Zhang , Yingchao Wang , Fang Zhang , Yingwei Wang , Qingyuan Zhang
DOI: 10.1016/J.HUMPATH.2011.11.018
关键词: Messenger RNA 、 Suppressor 、 Metastasis 、 Immunohistochemistry 、 Pathology 、 Polymerase chain reaction 、 Western blot 、 Biology 、 Biomarker (medicine) 、 Breast cancer
摘要: Suppression of cell spreading and migration by inhibitor growth 4 suggests that its loss may induce metastasis. Inhibitor expression level in 60 breast cancer tissues, 30 normal adjacent tissues from patients with benign hyperplasia was determined real-time polymerase chain reaction, Western blot, immunohistochemistry. The correlation between clinical stage, histologic grade, microvessel density analyzed. messenger RNA protein significantly lower than observed hyperplastic (P < .05). decreased increasing stage grade. Moreover, the presence lymph node metastasis correlated .01), a negative noted cancer. represent an important biomarker for assessing severity Further studies are required to fully evaluate diagnostic possible prognostic value determining levels
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