ING4 is negatively correlated with microvessel density in colon cancer
作者： Chun Lou , Shixiong Jiang , Xinggang Guo , Xin-shu Dong
DOI: 10.1007/S13277-012-0498-9
关键词: Pathology 、 Adenoma 、 Blot 、 Real-time polymerase chain reaction 、 Immunohistochemistry 、 Immunostaining 、 Stage (cooking) 、 Angiogenesis 、 Biology 、 Colorectal cancer
摘要: ING4 is a novel tumor suppressor which downregulated in number of cancers. In this study, we investigated the role angiogenesis colorectal carcinoma (CRC) patients. Semi-quantitative RT-PCR, western blots, and immunohistochemistry were used to determine mRNA protein expression CRC normal tissue from 60 specimens 30 colonic adenoma specimens. The correlation between clinical stage, histological grade as well lymph node metastasis was evaluated. Immunohistochemistry performed explore microvessel density (MVD) CRC. had significantly lower levels compared intestinal tissue. Immunostaining showed 38 (63.3 %), (100 %) cases mucosa, adenoma, mucosal tissue, respectively. Lower correlated with higher stage grade. patients without (0.41 ± 0.30 vs. 0.91 0.29 0.60 0.21 0.87 0.27, respectively; p < 0.001). Importantly, negatively MVD (p Our data suggest that are potential biomarker progression may inhibit growth by modulating
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