Quantitative myocardial perfusion analysis with a dual-bolus contrast-enhanced first-pass MRI technique in humans.
作者： Li-Yueh Hsu , Kenneth L. Rhoads , Jessica E. Holly , Peter Kellman , Anthony H. Aletras
DOI: 10.1002/JMRI.20502
关键词:
摘要: Materials and Methods: Rest dipyridamole stress perfusion imaging was performed on 10 healthy humans by administering gadolinium contrast using a dual-bolus protocol. Ventricular myocardial time-signal intensity curves were generated from series of T1-weighted images adjusted for surface-coil variations. Corrected signal then fitted fully quantitative model constrained deconvolution (MCD) to quantify MBF (mL/min/g) MPR. The results compared with semiquantitative enhancement ratio (CER) upslope index (SLP) measurements. Results: estimated MCD averaged 1.02 0.22 at rest 3.39 0.59 no overlap in measures. MPR 3.43 0.71, 1.91 0.65, 1.16 0.19 MCD, SLP, CER. Both parameters (SLP CER) significantly underestimated (P 0.001) failed completely discriminate perfusion. Conclusion: MRI fit within published ranges. Semiquantitative methods
core.ac.uk
sci-hub.se 参考文章(22)
Paul Meier, Kenneth L. Zierler, On the Theory of the Indicator-Dilution Method for Measurement of Blood Flow and Volume Journal of Applied Physiology. ,vol. 6, pp. 731- 744 ,(1954) , 10.1152/JAPPL.1954.6.12.731
Timothy F. Christian, Dan W. Rettmann, Anthony H. Aletras, Steve L. Liao, Joni L. Taylor, Robert S. Balaban, Andrew E. Arai, Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imaging. Radiology. ,vol. 232, pp. 677- 684 ,(2004) , 10.1148/RADIOL.2323030573
Michael Jerosch‐Herold, Ravi Teja Seethamraju, Cory M Swingen, Norbert M Wilke, Arthur E Stillman, None, Analysis of myocardial perfusion MRI Journal of Magnetic Resonance Imaging. ,vol. 19, pp. 758- 770 ,(2004) , 10.1002/JMRI.20065
Nidal Al-Saadi, Eike Nagel, Michael Gross, Bernhard Schnackenburg, Ingo Paetsch, Christoph Klein, Eckart Fleck, Improvement of myocardial perfusion reserve early after coronary intervention: assessment with cardiac magnetic resonance imaging. Journal of the American College of Cardiology. ,vol. 36, pp. 1557- 1564 ,(2000) , 10.1016/S0735-1097(00)00914-1
Kenneth L. Zierler, Theoretical Basis of Indicator-Dilution Methods For Measuring Flow and Volume Circulation Research. ,vol. 10, pp. 393- 407 ,(1962) , 10.1161/01.RES.10.3.393
Michael Jerosch-Herold, Norbert Wilke, Arthur E. Stillman, Robert F. Wilson, Magnetic resonance quantification of the myocardial perfusion reserve with a Fermi function model for constrained deconvolution. Medical Physics. ,vol. 25, pp. 73- 84 ,(1998) , 10.1118/1.598163
Dara L. Kraitchman, Norbert Wilke, Erik Hexeberg, Michael Jerosch-Herold, Ying Wang, Todd B. Parrish, Cheng-Ning Chang, Yi Zhang, Robert J. Bache, Leon Axel, Myocardial perfusion and function in dogs with moderate coronary stenosis Magnetic Resonance in Medicine. ,vol. 35, pp. 771- 780 ,(1996) , 10.1002/MRM.1910350519
N. Wilke, C. Simm, J. Zhang, J. Ellermann, X. Ya, H. Merkle, G. Path, H. Lüdemann, R. J. Bache, K. U??urbil, Contrast-enhanced first pass myocardial perfusion imaging: Correlation between myocardial blood flow in dogs at rest and during hyperemia Magnetic Resonance in Medicine. ,vol. 29, pp. 485- 497 ,(1993) , 10.1002/MRM.1910290410
Eike Nagel, Christoph Klein, Ingo Paetsch, Sabine Hettwer, Bernhard Schnackenburg, Karl Wegscheider, Eckart Fleck, Magnetic Resonance Perfusion Measurements for the Noninvasive Detection of Coronary Artery Disease Circulation. ,vol. 108, pp. 432- 437 ,(2003) , 10.1161/01.CIR.0000080915.35024.A9
Kensuke Sekihara, Steady-State Magnetizations in Rapid NMR Imaging Using Small Flip Angles and Short Repetition Intervals IEEE Transactions on Medical Imaging. ,vol. 6, pp. 157- 164 ,(1987) , 10.1109/TMI.1987.4307816